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Innovative clinical translation

Clinical connections are key to the NextGen Precision Health Initiative as we seek to accelerate the use of evidence-based and personalized decision-making in health care.

John Spertus speaks with colleagues
Dr. John Spertus, University of Missouri-Kansas City School of Medicine

In addition to MU Health, our health care system in Columbia, our universities partner with an extensive hospital network across the state. Some of these include University of Missouri-Kansas City’s (UMKC) partnerships with the Truman Medical Centers, Saint Luke’s and Children’s Mercy; and Missouri S&T’s partnership with Phelps Health. We also have built connections with Capital Region Medical Center in Jefferson City and the Veterans Affairs hospitals in Columbia and Kansas City. The power of clinical relationships in making a difference is illustrated by the story of Dr. John Spertus.

Dr. Spertus, an endowed chair and tenured professor at the UMKC School of Medicine and clinical director of outcomes research at Saint Luke’s Mid America Heart Institute, embodies the vision of translating evidence into practice. Since launching a health outcomes research program at UMKC and Saint Luke’s in 1996, Dr. Spertus has continually strived to develop better strategies to deliver more affordable patient-centered care. Through the flexibility of the UMKC and Saint Luke’s partnership, he found that he could bring ideas into practice more rapidly than at traditional, large, academic medical centers.

Dr. Spertus and his team developed the ePRISM® tool, which allows physicians to use patient-specific data to predict treatment outcomes for each individual patient. Already in use at Saint Luke’s, MU Health and Barnes, the tool predicts the risk of bleeding and acute kidney injury for patients undergoing angioplasty. This novel approach of estimating each patient’s risks to personalize treatment has reduced rates of bleeding and acute kidney injury by 40-80% in these hospitals and saves millions of dollars each year while improving outcomes. More than 20 hospitals throughout the country have adopted ePRISM® and it is not difficult to see how cultivating the clinical relationships across the UM System could continue to create new cost efficiencies for U.S. health care, elevating the value of our research.